Please wait...
Nepřihlášený uživatel
home
 → Research → Development or optimization of crystallization processes
iduzel: 61504
idvazba: 72957
šablona: stranka
čas: 10.8.2022 01:51:29
verze: 5054
uzivatel:
remoteAPIs:
branch: trunk
Obnovit | RAW

Development or optimization of crystallization processes

Influence of crystallization process conditions on resulting crystal size distribution


The aim of this project is general characterization of a crystallization processes, either cooled or antisolvent crystallizations. To this end, both in-situ and offline characterization methods are used, be it process analytical probes controlling the process in real time (Raman spectroscopy, optical camera, FBRM), or using electron or optical microscopy, X-ray diffraction, DSC and other methods. We start from crystal screening, moving up to larger scales. Using data obtained from the process, we focus on improving the crystal size distribution (CSD) using population balance modelling and scale-up of the crystallization. During the characterization, problems are encountered and solved, e.g. heterogeneous crystal growth, crystal agglomeration or how tableting can influence crystal agglomerates, using our resources to have an impact in the pharmaceutical industry.



👤 Dominik Martynek

Updated: 19.5.2022 14:25, Author: Kristýna Žemlová

UCT Prague
Technická 5
166 28 Prague 6 – Dejvice
IČO: 60461373 / VAT: CZ60461373

Czech Post certified digital mail code: sp4j9ch

Copyright: UCT Prague
Information provided by the Department of International Relations and the Department of R&D. Technical support by the Computing Centre.