b
Department of Chemical Engineering
University of Chemistry and Technology, Prague
Technická 3
166 28 Prague
Czechia
(see map)
e
+420 220 443251
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Technická 5
166 28 Prague 6 – Dejvice
IČO: 60461373 / VAT: CZ60461373
Czech Post certified digital mail code: sp4j9ch
Copyright: UCT Prague
Information provided by the Department of International Relations and the Department of R&D. Technical support by the Computing Centre.
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Blog posts written by students, about everything that life at BEAM lab group has to offer.
The ESAS 2022 & 17th CSSC
September 4th - 9th, 2022, Brno, Czech Republic
Between September 4th and 9th, our PhD student, Georgia Koutentaki, participated at European Symposium on Analytical Spectrometry ESAS 2022 & 17th Czech - Slovak Spectroscopic Conference which offered the newest trends and findings in numerous research fields related to analytical chemistry, such as Atomic Spectrometry (AAS, OES), Molecular spectrometry/spectroscopy (UV-Vis, NMR, Raman, IR, etc.), X-Ray Spectrometry (EDS, XRF, WDS, etc.) and many more.
Georgia presented her work "3D Raman mapping as an investigation tool for particle coating thickness" in a form of a poster.
The Orbis Summer School
September 7th - 9th, 2022, Prague, Czech Republic
Through September 7th to 9th, professor Šoóš and four of our PhD students - Adéla Koryťáková, Erika Hriňová, Dan Trunov and Dominik Martynek, took part in the ORBIS 4th summer school on Biopharmaceutical Evaluation of Dosage Forms and Drug Delivery. Apart from visiting workshops, we also helped with their organization.
We have attended many interesting talks on oral drug delivery, the differences in in vitro and in vivo dissolutions, problems commonly encountered and how to solve them, as well as how to model the GI tract. The poster section was also quite diverse in the works, with a competition for a best poster taking place. It was also an excellent networking opportunity.
We would like to thank Physiolution, Zentiva and University of Chemistry and Technology in Prague for organizing the event.
The Biolab renovation and moving to a temporary exile
July 7 - 8th, 2022
On July 7th and 8th, we joined forces to move out the equipments from the B30 lab (upstairs) to get it ready for an upcoming renovation. We ordered pizza to fuel up for moving of the heavier pieces of furniture. The class of B03 will serve us as temporary exile during the summer months. The renovation works in Biolab are expected to be finished by the second half of September and we will be welcomed back to work hopefully shortly after that.
The Lab trip to Kutná Hora
June 29th, 2022, Kutná Hora, Czech Republic
On June 29th, our group went on a one day trip to the town of Kutná Hora, where we had a delicious lunch and visited the Czech Museum of Silver. There, equipped with a helmet with a torch and a miner's coat, we learnt all about the silver mining technology of Middle age, production of silver coins and all about the lives of people in this industrial town. Eventhough the weather was partially against us, we still managed to grab some ice cream to finish the day on a sweet note.
The 48th International Conference of SSCHE & PERMEA 2022
May 23rd - 26th, 2022, hotel SOREA HUTNIK I, Tatranské Matliare, Slovakia
Between May 23 and 26, three PhD students of our research group, Pavel Krýsa, Dominik Martynek and Ondřej Šrom, participated at International Conference of Slovak Society of Chemical Engineering & membrane conference PERMEA at Tatranké Matliare, Slovakia.
The conference included competition for best poster which was awarded to PhD student of our group, Pavel Krýsa, for his work "Modelling of Bubble Breakage and Coalescence in Stirred and Sparged Bioreactor Using the Euler-Lagrange Approach".
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[obsah] => The BEAMlab was established in 2015 at the Department of Chemical Engineering at UCT Prague. Combining engineering concepts with material science knowledge the group is currently covering several emerging areas in drug delivery, biomolecule separation and biotechnology.
To improve the drug dissolution rate and bioavailability we are combining discovery of new multicomponent solid forms such as salts, co-crystals and amorphous forms with tunable particle size and surface chemistry. As a next step materials are produced in large scales for complete characterization of the materials including in-vitro dissolution and in-vivo bioavailability testing.
Porous materials with tunable porosity and pore size distribution are finding application in enzymatically catalyzed reactions towards synthesis of biodegradable polymers, photo degradation of drugs in environment, photo catalytic preparation of hydrocarbons from CO2 and others. These materials are prepared by controlled assembly process where nano- and micro-particles of various kind and bearing various surface functionalities are used as building blocks. Tuning of preparation conditions is used to prepare materials with desired properties.
In both above mentioned areas mixing is used for process intensification or process scale-up. Characterization of the mixing performance, mass transfer or conditions resulting in material damage by stirring is done via Computational Fluid Dynamics, and covers single phase as well as multiphase flows. Underlying mechanism controlling aggregation (coalescence), breakup, growth and metabolism of cells allows us to characterize systems from laboratory to production scale.
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prof. Ing. Miroslav Šoóš, Ph.D. |
Researchers
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Avanish Bharati |
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Argyro Chatziadi |
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Eliška Skořepová |
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Milena Šetka |
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Jeyalakshmi Velu |
Students
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Ashley H. George
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Tereza Havlůjová
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Erika Hriňová
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Nijad Ishak
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Petr Jelínek
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Adéla Koryťáková
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Georgina Koutentaki
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Pavel Krýsa
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Dominik Martynek
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Roopesh Mekkat
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Sreela Ramesh
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Ondřej Šrom
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Dominik Švára
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Dan Trunov
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Kristýna Žemlová
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Alumni
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Martina Ježková
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Edith Mawunya Kutorglo
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Ioannis Vasilopoulos
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Jose Francisco Wilson Collao
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- Ježková M., Jelínek P., Marelja O., Trunov D., Jarošová M., Slouka Z. and M. Šoóš, The preparation of mono- and multicomponent nanoparticle aggregates with layer-by-layer structure using emulsion templating method in microfluidics, Chemical Engineering Science 2022, 247, 117084 (Cover page)
- Šrom O., Trávníková V., Wutz J., Kuschel M., Unsoeld A., Wucherpfennig T. and M. Šoóš, Characterization of hydrodynamic stress in ambr® 250 bioreactor system and its impact on mammalian cell culture, Biochemical Engineering Journal (in press)
- Villela Zumaya A. L., Ulbrich P., Vilčáková J., Dendisova M., Fulem M., Šoóš M. and F. Hassouna, Multicomponent drug delivery systems based on PEGylated-poly (L-lactide-co-glycolide) and iron oxide nanoparticles, Journal of Drug Delivery Science and Technology 2021, 64, 102643
- Martinetz M., Kaiser F., Kellner M., Schlosser D., Lange A., Brueckner-Pichler M., Brocard C. and M. Šoóš, Hybrid Approach for Mixing Time Characterization and Scale-Up in Geometrical Nonsimilar Stirred Vessels Equipped with Eccentric Multi-Impeller Systems-An Industrial Perspective, Processes 2021, 9, 880
- Wilson J. F., Zahradník B., Šrom O., Jaquet B., Hassouna F., Hrdlička Z., Kosek J. and M. Šoóš, Study of shear-thinning effect between polymer nanoparticle surfaces during shear-induced aggregation, Industrial & Engineering Chemistry Research 2021, 60, 10654–10665
- Ježková M., Jelínek P., Šloufová I. and M. Šoóš, Preparation of gold snowflake-like particles and their application for surface-enhanced Raman spectroscopy, Surfaces and Interfaces 2021, 25, 101160
- Trunov D., Wilson J. F., Šrom O., Beranek J., Dammer O. and M. Šoóš, Monitoring the evolution in size of Valsartan particles during precipitation in the presence of nonionic surfactant, International Journal of Pharmaceutics 2021, 600, 120515
- Skořepová E., Rohlíček J., Chatziadi A., Zvoníček V., Jirát J., Čejka J., Ridvan L. and M. Šoóš, Low-Temperature Polymorphs of Lacosamide, Journal of Crystal Growth 2021, 562, 126085
- Kutorglo E. M., Muzika F., Hassouna F, Storti G., Kopecký D., Bleha R., Synytsya A., Sedlářová I. and M. Šoóš, Carboxyethyl-functionalized 3D porous polypyrrole synthesized using a porogen-free method for covalent immobilization of urease, Microporous and Mesoporous Materials 2021, 311, 110690
- Jirát J., Zvoníček V., Babor M., Skořepová E., Ridvan L., and M. Šoóš, Formation of the first non-isostructural cocrystal of Apremilast explained, Crystal Growth & Design 2020, 20, 9, 5785–5795
- Rohlíček J., Zvoníček V., Skořepová E., Šoóš M. and M. Dušek, Testing the flow through capillary for the study of re-solvation processes in pharmaceutical compounds, Powder Diffraction 2020, 35, 160-165
- Villela Zumaya A. L., Martynek D., Bautkinova T., Šoóš M., Ulbrich P., Raquez J-M., Dendisová M., Merna J., Vilčáková J., Kopecký D. and F. Hassouna, Self-assembly of Poly(L-lactide-co-glycolide) and Magnetic Nanoparticles into nanoclusters for Controlled Drug Delivery, European Polymer Journal 2020, 133, 109795
- Wilson J. W., Trunov D., Šrom O., Hassouna F., Štětina J., Kosek J. and M. Šoóš, Temperature modulated polymer nanoparticle bonding: A numerical and experimental study, Colloids and Surfaces A 2020, 601, 125010
- Perez A., Patino J., Soos M. and V. Morales, Morphology of Shear-Induced Colloidal Aggregates in Porous Media: Consequences for Transport, Deposition, and Re-entrainment, Environmental Science & Technology 2020, 54, 9, 5813-5821
- Vasilopoulos Y., Skořepová E. and M. Šoóš, COMF: Comprehensive model-fitting method for simulating isothermal and single-step solid-state reactions, Crystals 2020, 10, 139
- Kutorglo E. M., Kovačovič J., Trunov D., Hassouna F., Fučíková A., Kopecký D. and M. Šoóš, Preparation of monolithic CO2 adsorbents with hierarchical pore structure, Chemical Engineering Journal 2020, 388, 124308
- Chatziadi A., Skořepová E., Rohlíček J., Dušek M., Ridvan L. and M. Šoóš, Mechanochemically induced polymorphic transformations of Sofosbuvir, Crystal Growth & Design 2020, 20, 139−147
- Zubov A., Wilson J. F., Kroupa M., M. Šoóš and J. Kosek, Numerical Modeling of Viscoelasticity in Particle Suspensions Using the Discrete Element Method, Langmuir 2019, 35, 12754-12764
- Kim H., Hassouna F., Muzika F., Arabacı M., Kopecký D., Sedlářová I. and M. Šoóš, Urease adsorption immobilization on ionic liquid-like macroporous polymeric support, Journal of Materials Science 2019, 54, 14884–14896
- Jirát J., Ondo D., Babor M., Ridvan L. and M. Šoóš, Complex methodology for rational design of Apremilast-Benzoic acid co-crystallization process, International Journal of Pharmaceutics 2019, 570, 118639
- Hassouna F., Abo El Dahab M., Fulem M., De Lima Haeik A., Kopecký D. and M. Šoóš, Multi-scale analysis of amorphous solid dispersions prepared by freeze drying of ibuprofen loaded acrylic polymer nanoparticles, Journal of Drug Delivery Science and Technology 2019, 53, 101182
- Bertrand V., Karst D., Bachmann A., Cantalupo K., Soos M. and M. Morbidelli, Transcriptome and Proteome analysis of steady-state in a perfusion CHO cell culture process, Biotechnology and Bioengineering 2019, 116, 1959– 1972
- Kutorglo E. A., Hassouna F., Beltzung A., Kopecký D., Sedlářová I. and M. Šoóš, Nitrogen-rich hierarchically porous polyaniline-based sorbents for carbon dioxide (CO2) capture, Chemical Engineering Journal 2019, 360, 1199-1212
- Wilson J. F., Kroupa M., Kosek J. and M. Soos, Numerical study of soft nanoparticles interaction, Langmuir 2018, 34, 15600-15611
- Kutorglo E. A., Hassouna F., Kopecký D., Fišer L., Sedlářová I., Zadražil A. and M. Šoóš, Synthesis of conductive macroporous composite polymeric materials using porogen-free method, Colloids and Surfaces A. 2018, 557, 137-145
- Hassouna F., Korbelářová J., Jacquet B., Kutorglo E. M., Kopecký D., Ulbrich P., Fulem M., Hrdlička Z. and M. Šoóš, An environmentally benign methodology to elaborating polymer nanocomposites with tunable properties using core-shell nanoparticles and cellulose nanocrystals, Colloids and Surfaces A. 2018, 553, 169–179
- Bertrand V., Vogg S., Villiger T. K., Soos M., Stettler M., Broly H. and M. Morbidelli, Proteomic analysis of micro scale bioreactors as scale-down model for a mAb producing CHO industrial fed-batch platform, Journal of Biotechnology 2018, 279, 27-36
- Zvoníček V., Skořepová E., Dušek M., Žvátora P. and M. Šoóš, Ibrutinib Polymorphs: Crystallographic Study, Crystal Growth & Design 2018, 18, 1315–1326
- Villiger T.K., Neunstoecklin B., Karst D., Lucas E., Stettler M., Broly H., Morbidelli M. and M. Soos, Experimental and CFD physical characterization of animal cell bioreactors: From micro- to production scale, Biochemical Engineering Journal 2018, 131, 84-94
- Hutter S., Villiger T. K., Brühlmann D., Stettler M., Broly H., Soos M. and R. Gunawan, Glycosylation flux analysis reveals dynamic changes of intracellular glycosylation flux distribution in Chinese hamster ovary fed-batch cultures, Metabolic Engineering 2017, 43, 9–20
- Karst D. J., Steinhoff R., Kopp M., Soos M., Zenobi R. and M. Morbidelli, Isotope labeling to determine the dynamics of metabolic response in CHO cell perfusion cultures using MALDI-TOF-MS, Biotechnology Progress 2017, 33, 1630–1639
- Karst D. J., Steinhoff R., Kopp M., Serra E., Soos M., Zenobi R. and M. Morbidelli, Intracellular CHO cell metabolite profiling reveals steady-state dependent metabolic fingerprints in perfusion culture, Biotechnology Progress 2017, 33, 879–890
- Karst D. J., Scibona E., Serra E., Bielser J. M., Settler M., Solacoup J., Broly H., Soos M., Morbidelli M. and T. K. Villiger, Modulation and modeling of monoclonal antibody N-linked glycosylation in mammalian cell perfusion reactors, Biotechnology and Bioengineering 2017, 117, 1978-1990
- Zvoníček V., Skořepová E., Dušek M., Babor M., Žvátora P. and M. Šoóš, First Crystal Structures of Pharmaceutical Ibrutinib: Systematic Solvate Screening and Characterization, Crystal Growth & Design 2017, 17, 3116–3127
- Jaquet B., Lazzari S., Colonna L., Colombo G., Soos M. and M. Morbidelli, Effects of Coalescence on Shear-Induced Gelation of Colloids, Langmuir 2017, 33, 1180–1188
- Karst D. J., Steinebach F., Soos M. and M. Morbidelli, Process performance and product quality in an integrated continuous antibody production process, Biotechnology and Bioengineering 2017, 114, 298-307 Read article
- Kroupa M., Soos M and J. Kosek, Slip on Particle Surface as the Possible Origin of Shear Thinning in non-Brownian Suspensions, Physical Chemistry Chemical Physics 2017, 19, 5979-5984 Read article
- Sokolov M., Ritscher J., MacKinnon N., Bielser J.M., Bruhlmann D., Rothenhausler D., Thanei G., Soos M., Stettler M., Souquet J., Broly H., Morbidelli M. and A. Butte, Robust factor selection in early cell culture process development for the production of a biosimilar monoclonal antibody, Biotechnology Progress 2017, 33, 181-191 Read article
- Jaquet B., Lazzari S., Colonna L., Colombo G., Soos M. and M. Morbidelli, Effects of Coalescence on Shear-Induced Gelation of Colloids, Langmuir 2017, 33, 1180-1188 Read article
- Zvonicek V., Skorepova E., Dusek M., Babor M., Zvatora P. and M. Soos, First Crystal Structures of Pharmaceutical Ibrutinib: Systematic Solvate Screening and Characterization, Crystal Growth & Design 2017, 17, 3116-3127 Read article
- Karst D. J., Scibona E., Serra E., Bielser J. M., Settler M., Solacoup J., Broly H., Soos M., Morbidelli M. and T. K. Villiger, Modulation and modeling of monoclonal antibody N-linked glycosylation in mammalian cell perfusion reactors, Biotechnology and Bioengineering 2017, 117, 1978-1990
- Saha D., Babler M.U., Holzner M., Soos M., Luthi B., Liberzon A. and W. Kinzelbach, Breakup of Finite-Size Colloidal Aggregates in Turbulent Flow Investigated by Three-Dimensional (3D) Particle Tracking Velocimetry, Langmuir 2016, 32, 55-65
- Neunstocklin B., Villiger T. K., Lucas E., Stettler M., Broly H., Morbidelli M. and M. Soos, Pilot scale verification of maximum tolerable hydrodynamic stress for mammalian cell culture, Applied Microbiology and Biotechnology 2016, 100, 3489-3498
- Steinhoff R., Karst D., Steinebach F., Kopp M., Schmidt G., Stettler A, Krismer J, Soos M., Pabst M., Hierlemann A., Morbidelli M. and R. Zenobi, Microarray-based MALDI-TOF mass spectrometry enables monitoring of monoclonal antibody production in batch and perfusion cell cultures, Methods 2016, 104, 33-40
- Karst D. J., Serra E., Villiger T. K., Soos M. and M. Morbidelli, Characterization and comparison of ATF and TFF in stirred bioreactors for the continuous production of therapeutic proteins, Biochemical Engineering Journal 2016, 110, 17-26
- Ullrich M., Hasa J., Hanus J., Soos M. and F. Stepanek, Perikinetic aggregation and stabilisation of cationic liposome clusters, Powder Technology 2016, 295, 115-121
- Villiger T. K., Steinhoff R. F., Ivarsson M., Solacroup T., Stettler M., Broly H., Krismer J., Pabst M., Zenobi R., Morbidelli M. and M. Soos, High-throughput profiling of nucleotides and nucleotide sugars to evaluate their impact on antibody N-glycosylation, Journal of Biotechnology 2016, 229, 3-12
- Vonka M., Storti G., Morbidelli M. and M. Soos, Viscosity and drop size evolution during suspension polymerization, AICHE Journal 2016, 62, 4229-4239
- Kroupa M., Vonka M., Soos M. and J. Kosek, Utilizing the Discrete Element Method for the Modeling of Viscosity in Concentrated Suspensions, Langmuir 2016, 32, 8451-8460
- Villiger T. K., Roulet A., Perilleux A., Stettler M., Broly H., Morbidelli M. and M. Soos, Controlling the time evolution of mAb N-linked glycosylation - Part I: Micro-bioreactor experiments, Biotechnology Progress 2016, 32, 1123-1134
- Villiger T. K., Scibona E., Stettler M., Broly H., Morbidelli M. and M. Soos, Controlling the time evolution of mAb N-linked glycosylation - Part II: Model-based predictions, Biotechnology Progress, Biotechnology Progress 2016, 32, 1135-1148
- Steinhoff R. F., Ivarsson M., Habicher T., Villiger T. K., Boertz J., Krismer J., Fagerer S., Soos M., Morbidelli M., Pabst M. and R. Zenobi, High-throughput nucleoside phosphate monitoring in mammalian cell fed-batch cultivation using quantitative matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, Biotechnology Journal 2015, 10, 190-198
- Garcia Munzer D. G., Ivarsson M., Usaku C., Habicher T., Soos M., Morbidelli M., Pistikopoulos E. N. and A. Mantalaris, An Unstructured Model of Metabolic and Temperature Dependent Cell Cycle Arrest in Hybridoma Batch and Fed-Batch Cultures, Engineering Journal 2015, 93, 260-273
- Ivarsson M., Noh H., Morbidelli M. and M. Soos, Insights into pH-induced Metabolic Switch by Flux Balance Analysis, Biotechnology Progress 2015, 31, 347-357
- Villiger T. K., Morbidelli M. and M. Soos, Experimental determination of maximum effective hydrodynamic stress in multiphase flow using shear sensitive aggregates, AICHE Journal 2015, 61, 1735-1744
- Neunstocklin B., Stettler M., Solacroup T., Broly H., Morbidelli M. and M. Soos, Determination of the maximum operating range of hydrodynamic stress in mammalian cell culture, Journal of Biotechnology 2015, 194, 100-109
- Vonka M. and M. Soos, Characterization of liquid-liquid dispersions with variable viscosity by coupled CFD with Population Balances, AICHE Journal 2015, 61, 2403-2414
- Lamprou A., Gavriilidou A. F. M., Storti G., Soos M. and M. Morbidelli, Application of Polymeric Macroporous Supports for Temperature-Responsive Chromatography of Pharmaceuticals, Journal of Chromatography A 2015, 1407, 90-99
- Kroupa M., Vonka M., Soos M. and J. Kosek, Size and Structure of Clusters Formed by Shear Induced Coagulation: Modeling by Discrete Element Method, Langmuir 2015, 31, 7727-7737
- Hang I., Lin Ch., Grant O., Fleurkens S., Villiger T.K., Soos M., Morbidelli M., Woods R., Gauss R. and M. Aebi, Analysis of site-specific N-glycan remodelling in the ER and the Golgi, Glycobiology 2015, 25, 1335-1349
- Sokolov M., Butte A., Soos M., Leardi R., Neunstocklin B., Solacroup T., Stettler M., Broly H., Morbidelli M., Fingerprint detection and process prediction by multivariate analysis of fed-batch monoclonal antibody cell culture data, Biotechnology Progress 2015, 31, 1633-1644
- Brand B., Morbidelli M. and M. Soos, Shear-Induced Reactive Gelation, Langmuir 2015, 31, 12727-12735
- Codari F., Moscatelli D. S., Furlan M., Lattuada M., Morbidelli M and M. Soos, Synthesis of Hetero-Nano-Clusters: The Case of Polymer-Magnetite Systems, Langmuir 2014, 30, 2266-2273
- Lamprou A., Kose I., Storti G., Morbidelli M. and M. Soos, Synthesis of Macroporous Polymer Particles using Reactive Gelation under Shear, Langmuir 2014, 30, 6946-6953
- Ivarsson M., Villiger T. K., Morbidelli M. and M. Soos, Evaluating the Impact of Cell Culture Process Parameters on Monoclonal Antibody N-Glycosylation, Journal of Biotechnology 2014, 188, 88-96
- Sieck J. B., Budach W. E., Suemeghy Z., Leist Ch., Villiger T. K., Morbidelli M. and M. Soos, Adaptation for Survival: Phenotype and Transcriptome Response of CHO Cells to Elevated Stress Induced by Agitation and Sparging, Journal of Biotechnology 2014, 189, 94-103
- Lamprou A., Kose I., Pen?a Z. A., Storti G., Morbidelli M. and M. Soos, Macroporous Polymer Particles via Reactive Gelation under Shear: Effect of Primary Particle Properties and Operating Parameters, Langmuir 2014, 30, 13970-13978
- Saha D., Soos M., Luthi B., Holzner M., Liberzon A., Babler M. U. and W. Kinzelbach, Experimental characterization of breakage rate of colloidal aggregates in axisymmetric extensional flow, Langmuir 2014, 30, 14385-14395
- de Neuville B. C., Lamprou A., Morbidelli M. and M Soos, Perfusive ion-exchange chromatographic materials with high capacity, Journal of Chromatography A 2014, 1374, 180-188
- Sieck J. B., Cordes T., Budach W. E., Rhiel M. H., Suemeghy Z., Leist Ch., Villiger T. K., Morbidelli M. and M. Soos, Development of a scale-down model of hydrodynamic stress to study the performance of an industrial CHO cell line under simulated production scale bioreactor conditions, Journal of Biotechnology 2013, 164, 41-19
- Soos M., Marchisio D. L. and J. Sefcik, Assessment of gel formation in colloidal dispersions during mixing in turbulent jets, AICHE Journal 2013, 59, 4567-4581
- Soos M., Kaufmann R., Winteler R., Kroupa M. and B. Luthi, Determination of Maximum Turbulent Energy Dissipation Rate generated by a Rushton Impeller through Large Eddy Simulation, AICHE Journal 2013, 59, 3642-3658
- Lazzari S., Maggioni G. M., Soos M., Wu H. and M. Morbidelli, Shear-Stability and Gelation of Inverse Latexes, Soft Matter 2013, 9, 10866-10876
- Moussa A. S., Lattuada M., Conchuir B.O., Zaccone A., Morbidelli M. and M. Soos, Flow-Induced Aggregation and Breakup of Particle Clusters Controlled by Surface Nanoroughness, Langmuir 2013, 29, 14386-14395
- Codari F., Lazzari S., Soos M., Storti G., Morbidelli M. and D. Moscatelli, Kinetics of the hydrolytic degradation of poly(lactic acid), Polymer Degradation and Stability 2012, 97, 2460-2466
- Sorg R., Tanzeglock T., Soos M., Morbidelli M., Perilleux A., Solacroup T. and H. Broly, Minimizing hydrodynamic stress in mammalian cell culture through the lobed Taylor-Couette bioreactor, Biotechnology Journal 2011, 6, 1504-1515
- Harshe Y., Lattuada M. and M. Soos, Experimental and modeling study of breakage and restructuring of open and dense colloidal aggregates, Langmuir 2011, 27, 5739-5752
- Trtik P., Soos M., Muench B., Lamprou A., Mokso R. and M. Stampanoni, Quantification of a single aggregate inner porosity and pore accessibility using hard X-ray Phase-Contrast Nanotomography, Langmuir 2011, 27, 12788-12791
- Soos M., Ehrl L., Babler M. U. and M. Morbidelli, Aggregate breakup in a contracting nozzle, Langmuir 2010, 26, 10-18
- Ehrl L., Soos M., Wu H. and M. Morbidelli, Effect of flow field heterogeneity in coagulators on aggregate size and structure, AICHE Journal 2010, 56, 2573-2587
- Babler M. U., Moussa A. S., Soos M. and M. Morbidelli, Structure and kinetics of shear aggregation in turbulent flows. I. Early stage of aggregation, Langmuir 2010, 26, 13142-13152
- Ehrl L., Jia Z., Wu H., Lattuada M., Soos M. and M. Morbidelli, Role of counterion association in colloidal stability, Langmuir 2009, 25, 2696-2702
- Ehrl L., Soos M. and M. Morbidelli, Dependence of initial cluster aggregation kinetics on shear rate for particles of different sizes under turbulence, AICHE Journal 2009, 55, 3076-3087
- Tanzeglock T., Soos M. and M. Morbidelli, Prediction of cell damage in stirred bioreactors-from small-scale model systems to a novel bioreactor design, New Biotechnology 2009, 25, S190-S191
- Tanzeglock T., Soos M., Stephanopoulos G. and M. Morbidelli, Induction of mammalian cell death by simple shear and extensional flows, Biotechnology and Bioengineering 2009, 104, 360-370
- Zaccone A., Soos M., Lattuada M., Wu H. and M. Morbidelli, Breakup of dense colloidal aggregates under hydrodynamic stresses, Physical Review E. 2009, 79, 061401
- Ehrl L., Soos M. and Lattuada M., Generation and geometrical analysis of dense clusters with variable fractal dimension, Journal of Physical Chemistry B 2009, 113, 10587-10599
- Soos M., Lattuada M. and J. Sefcik, Interpretation of light scattering and turbidity measurements in aggregated systems: Effect of Multiple-Light Scattering, Journal of Physical Chemistry B 2009, 113, 14962-14970
- Soos M., Moussa A. S., Ehrl L., Sefcik J., Wu H. and M. Morbidellis, Effect of shear rate on aggregates size and morphology investigated under turbulent conditions in stirred tank, Journal of Colloid Interface Science 2008, 319, 577-589
- Ehrl L., Soos M. and M. Morbidelli, Dependence of aggregate strength, structure, and light scattering properties on primary particle size under turbulent conditions in stirred tank, Langmuir 2008, 24, 3070-3081
- Soos M., Moussa A. S., Ehrl L., Sefcik J., Wu H. and M. Morbidelli, Dynamic response studies on aggregation and breakage dynamics of colloidal dispersions in stirred tanks, Journal of Dispersion Science and Technology 2008, 29, 605-610
- Ehrl L., Soos M. and M. Morbidelli, Sizing polydisperse dispersions by focused beam reflectance and small angle static light scattering, Particle & Particle System Characterization 2007, 23, 438-447
- Soos M. Wu H. and M. Morbidelli, Taylor-Couette unit with a lobed inner cylinder cross section, AIChE Journal 2007, 53, 1109-1120
- Soos M., Rajniak P. and F. Stepanek, Percolation models of adsorption-desorption equilibria and kinetics for systems with hysteresis, Colloids and Surfaces A. 2007, 300, 191-203
- Stepanek F., Soos M. and P. Rajniak, Characterization of porous media by the virtual capillary condensation method, Colloids and Surfaces A. 2007, 300, 11-22
- Moussa A., Soos M., Sefcik J. and M. Morbidelli, Effect of the solid volume fraction on aggregation and breakage of colloidal suspensions in batch and continuous stirred tanks, Langmuir 2007, 23, 1664-1673
- Soos M., Sefcik J. and M. Morbidelli, Master curves for aggregation and gelation: Effects of cluster structure and polydispersity, Industrial & Engineering Chemistry Research 2007, 46, 1709-1720
- Soos M., Wang L., Fox R.O., Sefcik J. and M. Morbidelli, Population balance modeling of aggregation and breakage in turbulent Taylor-Couette flow, Journal of Colloid Interface Science 2007, 307, 433-446
- Marchisio D. L., Soos M., Sefcik J and M. Morbidelli, Role of turbulent shear rate distribution in aggregation and breakage processes, AIChE Journal 2006, 52, 158-173
- Marchisio D. L., Soos M., Sefcik J., Morbidelli M., Barresi A. A. and G. Baldi, Effect of fluid dynamics on particle size distribution in particulate processes, Chemical Engineering and Technology 2006, 29, 191-199
- Soos M, Sefcik J and M. Morbidelli, Investigation of aggregation, breakage and restructuring kinetics of colloidal dispersions in turbulent flows by population balance modeling and static light scattering, Chemical Engineering Science 2006, 61, 2349-2363
- Sefcik J., Soos M., Vaccaro A. and M. Morbidelli, Effects of mixing on aggregation and gelation of nanoparticles, Chemical Engineering and Processing 2006, 45, 936-943
- Waldner M. H., Sefcik J., Soos M. and M. Morbidelli, Initial growth kinetics of aggregates in turbulent coagulator, Powder Technology 2005, 156, 226-234
- Soos M., Graczova E, Markos J., Molnar A. and P. Steltenpohl, Design and simulation of a distillation column for separation of dichloropropane from a multicomponent mixture, Chemical Engineering and Processing 2003, 42, 273-284
- Soos M. and P. Rajniak, Percolation models of adsorption-desorption kinetics with hysteresis, Chemical Papers 2002, 56, 62-69
- Smejkal Q. and M. Soos, Comparison of computer simulation of reactive distillation using ASPEN PLUS and HYSYS software, Chemical Engineering and Processing 2002, 41, 413-418
- Markos J., Soos M. and L. Jelemensky, Design and simulation of a reactor for the chlorination of acetone in gaseous phase, Chemical Engineering Science 2001, 56, 627-632
- Soos M. and P. Rajniak, Percolation model of adsorption-desorption equilibria with hysteresis, Chemical Papers 2001, 55, 391-396
- Soos M., Rajniak P. and R. Zajdlik, Mathematical and experimental modelling of sorption processes in a fixed bed adsorber, Chemical Papers 2000, 54, 489-495
- Stepanek F., Kubicek M., Marek M., Soos M., Rajniak P, and R. T. Yang, On the modeling of PSA cycles with hysteresis-dependent isotherms, Chemical Engineering Science 2000, 55, 431-440
- Markos J., Jelemensky L, Soos M. and V. Camaj, Selective chlorination of acetone in the gas phase, Industrial & Engineering Chemistry Research 1999, 53, 349-346
- Rajniak P., Soos M. and R.T. Yang, Unified network model for adsorption-desorption in systems with hysteresis, AIChE Journal 1999, 45, 735-750
Books and contributions to books
- Babler M.U., Liberzon A., Saha D., Holzner M., Soos M., Luthi B. and W. Kinzelbach (2018) Breakup of Individual Colloidal Aggregates in Turbulent Flow Investigated by 3D Particle Tracking Velocimetry, in Multi-Phase Flow Phenomena and Applications, World Scientific Publishing Co, Singapore
- Eon-Duval, A., Gleixner, R., Valax, P., Soos, M., Neunstoecklin, B., Morbidelli, M. and Broly, H. (2014) Quality by Design Applied to a Fc-Fusion Protein: A Case Study, in Therapeutic Fc-Fusion Proteins (eds S. M. Chamow, T. Ryll, H. B. Lowman and D. Farson), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germnay
Patents
- Soos M., Lamprou A., Brand B., Storti G., Morbidelli M., Method for the preparation of macroporous particles and macroporous particles obtained using such a method, 2012, EU Patent 12007949
- Soos, M, Wu, H., Morbidelli, M., Rotating stirring device with substantially narrow distribution of energy dissipation rate, 2003, EU Patent 03019330.4
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To improve the drug dissolution rate and bioavailability we are combining discovery of new multicomponent solid forms such as salts, co-crystals and amorphous forms with tunable particle size and surface chemistry. As a next step materials are produced in large scales for complete characterization of the materials including in-vitro dissolution and in-vivo bioavailability testing.
Porous materials with tunable porosity and pore size distribution are finding application in enzymatically catalyzed reactions towards synthesis of biodegradable polymers, photo degradation of drugs in environment, photo catalytic preparation of hydrocarbons from CO2 and others. These materials are prepared by controlled assembly process where nano- and micro-particles of various kind and bearing various surface functionalities are used as building blocks. Tuning of preparation conditions is used to prepare materials with desired properties.
In both above mentioned areas mixing is used for process intensification or process scale-up. Characterization of the mixing performance, mass transfer or conditions resulting in material damage by stirring is done via Computational Fluid Dynamics, and covers single phase as well as multiphase flows. Underlying mechanism controlling aggregation (coalescence), breakup, growth and metabolism of cells allows us to characterize systems from laboratory to production scale.
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Department of Chemical Engineering
University of Chemistry and Technology, Prague
Technická 3
166 28 Prague
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(see map)
e
+420 220 443251
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